Studies on allergoids from naturally occurring allergens IV. Efficacy and safety of long-term allergoid treatment of ragweed hay fever
PS Norman, LM Lichtenstein, DG Marsh - Journal of Allergy and Clinical …, 1981 - Elsevier
An allergoid of ragweed was produced by treating dialyzed defatted pollen extract under
mild conditions with formaldehyde. This modified antigen was found to have the desirable
properties of reduced allergenicity, retained antigenicity, and prolonged stability for IgG
antibody production. A series of trials was carried out in ragweed-allergic patients from 1972
to 1978. In 1972 it was demonstrated that on average, allergoid had on the basis of antigen
E content about one fiftieth the ability of unaltered whole ragweed extract (allergen) to …
mild conditions with formaldehyde. This modified antigen was found to have the desirable
properties of reduced allergenicity, retained antigenicity, and prolonged stability for IgG
antibody production. A series of trials was carried out in ragweed-allergic patients from 1972
to 1978. In 1972 it was demonstrated that on average, allergoid had on the basis of antigen
E content about one fiftieth the ability of unaltered whole ragweed extract (allergen) to …