[PDF][PDF] Routes to transplant tolerance versus rejection: the role of cytokines
PT Walsh, TB Strom, LA Turka - Immunity, 2004 - cell.com
PT Walsh, TB Strom, LA Turka
Immunity, 2004•cell.comThe alloimmune response can be divided into specific junctures where critical decisions
between tolerance and immunity are made which define the outcome of the transplant. At
these" decision nodes" various cytokines direct alloresponsive T cells to develop either a
proinflammatory response aimed at graft destruction or an immunoregulatory response
facilitating graft acceptance. This review will focus on the role of these cytokines in
influencing the progression of an alloimmune response leading ultimately to either allograft …
between tolerance and immunity are made which define the outcome of the transplant. At
these" decision nodes" various cytokines direct alloresponsive T cells to develop either a
proinflammatory response aimed at graft destruction or an immunoregulatory response
facilitating graft acceptance. This review will focus on the role of these cytokines in
influencing the progression of an alloimmune response leading ultimately to either allograft …
Abstract
The alloimmune response can be divided into specific junctures where critical decisions between tolerance and immunity are made which define the outcome of the transplant. At these "decision nodes" various cytokines direct alloresponsive T cells to develop either a proinflammatory response aimed at graft destruction or an immunoregulatory response facilitating graft acceptance. This review will focus on the role of these cytokines in influencing the progression of an alloimmune response leading ultimately to either allograft survival or rejection.
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