Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties
Although Mycobacterium kansasii has emerged as an important pathogen frequently
encountered in immunocompromised patients, little is known about the mechanisms of M.
kansasii pathogenicity. Lipoarabinomannan (LAM), a major mycobacterial cell wall
lipoglycan, is an important virulence factor for many mycobacteria, as it modulates the host
immune response. Therefore, the detailed structures of the of M. kansasii LAM (KanLAM), as
well as of its biosynthetic precursor lipomannan (KanLM), were determined in a clinical …
encountered in immunocompromised patients, little is known about the mechanisms of M.
kansasii pathogenicity. Lipoarabinomannan (LAM), a major mycobacterial cell wall
lipoglycan, is an important virulence factor for many mycobacteria, as it modulates the host
immune response. Therefore, the detailed structures of the of M. kansasii LAM (KanLAM), as
well as of its biosynthetic precursor lipomannan (KanLM), were determined in a clinical …
