[HTML][HTML] Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid β–infused rats
M Hashimoto, Y Tanabe, Y Fujii, T Kikuta… - The Journal of …, 2005 - Elsevier
We investigated whether administration of docosahexaenoic acid (DHA), a major (n-3) fatty
acid of the brain, ameliorates the impairment of learning ability in an animal model of
Alzheimer's disease (AD), rats infused with amyloid-β (Aβ) peptide (1–40) into the cerebral
ventricle. Inbred 3rd generation male rats (20 wk old) fed a fish oil–deficient diet were
randomly divided into 4 groups: a vehicle group, an Aβ peptide-infused group (Aβ group), a
DHA group, and an Aβ+ DHA group. A mini-osmotic pump filled with Aβ peptide or vehicle …
acid of the brain, ameliorates the impairment of learning ability in an animal model of
Alzheimer's disease (AD), rats infused with amyloid-β (Aβ) peptide (1–40) into the cerebral
ventricle. Inbred 3rd generation male rats (20 wk old) fed a fish oil–deficient diet were
randomly divided into 4 groups: a vehicle group, an Aβ peptide-infused group (Aβ group), a
DHA group, and an Aβ+ DHA group. A mini-osmotic pump filled with Aβ peptide or vehicle …
