Evidence of tubular hypoxia in the early phase in the remnant kidney model
K Manotham, T Tanaka, M Matsumoto… - Journal of the …, 2004 - journals.lww.com
The remnant kidney model is a mainstay in the study of progressive renal disease. The
earliest changes in this model result from glomerular hemodynamic alterations. Given that
progressive renal disease is the result of subsequent interstitial damage initiated by
undetermined pathogenic factors, the authors investigated the role of hypoxia as a
pathogenic factor in tubulointerstitial damage after renal ablation in rats. Cortical tissue
hypoxia in the early phase (4 and 7 d) in remnant kidney rats, sham-operated rats, and …
earliest changes in this model result from glomerular hemodynamic alterations. Given that
progressive renal disease is the result of subsequent interstitial damage initiated by
undetermined pathogenic factors, the authors investigated the role of hypoxia as a
pathogenic factor in tubulointerstitial damage after renal ablation in rats. Cortical tissue
hypoxia in the early phase (4 and 7 d) in remnant kidney rats, sham-operated rats, and …
