[HTML][HTML] Coronavirus replication complex formation utilizes components of cellular autophagy
E Prentice, WG Jerome, T Yoshimori… - Journal of Biological …, 2004 - ASBMB
The coronavirus mouse hepatitis virus (MHV) performs RNA replication on double
membrane vesicles (DMVs) in the cytoplasm of the host cell. However, the mechanism by
which these DMVs form has not been determined. Using genetic, biochemical, and cell
imaging approaches, the role of autophagy in DMV formation and MHV replication was
investigated. The results demonstrated that replication complexes co-localize with the
autophagy proteins, microtubule-associated protein light-chain 3 and Apg12. MHV infection …
membrane vesicles (DMVs) in the cytoplasm of the host cell. However, the mechanism by
which these DMVs form has not been determined. Using genetic, biochemical, and cell
imaging approaches, the role of autophagy in DMV formation and MHV replication was
investigated. The results demonstrated that replication complexes co-localize with the
autophagy proteins, microtubule-associated protein light-chain 3 and Apg12. MHV infection …