Regulation of cytochromes P450 during inflammation and infection
ET Morgan - Drug metabolism reviews, 1997 - Taylor & Francis
Drug metabolism reviews, 1997•Taylor & Francis
In humans and experimental animals. infections or inflammatory stimuli cause changes in
the activities and expression levels of various forms of cytochrome P450 (P450) in the liver.
kidney. and brain. Many important drugs rely on hepatic metabolism by P450 for clearance
from the circulation and for pharmacological inactivation. Conversely. some drugs must be
converted in the body to their pharmacologically or toxicologically active
the activities and expression levels of various forms of cytochrome P450 (P450) in the liver.
kidney. and brain. Many important drugs rely on hepatic metabolism by P450 for clearance
from the circulation and for pharmacological inactivation. Conversely. some drugs must be
converted in the body to their pharmacologically or toxicologically active
In humans and experimental animals. infections or inflammatory stimuli cause changes in the activities and expression levels of various forms of cytochrome P450 (P450) in the liver. kidney. and brain. Many important drugs rely on hepatic metabolism by P450 for clearance from the circulation and for pharmacological inactivation. Conversely. some drugs must be converted in the body to their pharmacologically or toxicologically active
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