[HTML][HTML] β-arrestin goes nuclear
JM Beaulieu, MG Caron - Cell, 2005 - cell.com
Cell, 2005•cell.com
Arrestins have important roles in the cytoplasm and at the plasma membrane, including the
desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of
Cell, Kang et al.(2005) provide evidence that β-arrestin 1 moves to the nucleus in response
to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at
specific gene promoters.
desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of
Cell, Kang et al.(2005) provide evidence that β-arrestin 1 moves to the nucleus in response
to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at
specific gene promoters.
Summary
Arrestins have important roles in the cytoplasm and at the plasma membrane, including the desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of Cell, Kang et al. (2005) provide evidence that β-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters.
cell.com
