Is loss of podocyte foot processes necessary for the induction of proteinuria?
SA Karumanchi, FH Epstein, IE Stillman - American journal of kidney …, 2005 - ajkd.org
Good et al present a fascinating case of a 38-year-old man with nephrotic-range proteinuria.
1 The biopsy findings were limited to largely intact foot processes with effacement noted in
only 20% to 30% of the capillary loops. In the Discussion, they state that,“[i] n essentially all
diseases with nephrotic-range proteinuria, there is damage to the visceral epithelial cells,
effaced foot processes, and loss of slit diaphragms.” 1 Most proteinuric renal diseases such
as diabetic nephropathy and focal segmental glomerulosclerosis have loss/effacement of …
1 The biopsy findings were limited to largely intact foot processes with effacement noted in
only 20% to 30% of the capillary loops. In the Discussion, they state that,“[i] n essentially all
diseases with nephrotic-range proteinuria, there is damage to the visceral epithelial cells,
effaced foot processes, and loss of slit diaphragms.” 1 Most proteinuric renal diseases such
as diabetic nephropathy and focal segmental glomerulosclerosis have loss/effacement of …
