Neuronal calcium sensor-1 (NCS-1) or the originally identified homologue frequenin
belongs to a superfamily of EF-hand calcium binding proteins. Although NCS-1 is thought to
enhance synaptic efficacy or exocytosis mainly by activating ion channel function, the
detailed molecular basis for the enhancement is still a matter of debate. Here, mechanisms
underlying the NCS-1-evoked enhancement of exocytosis were investigated using PC12
cells overexpressing NCS-1. NCS-1 was found to have a broad distribution in the cells being …