Activation of the inositol 1, 4, 5-trisphosphate receptor by the calcium storage protein chromogranin A
EC Thrower, HY Park, SH So, SH Yoo… - Journal of Biological …, 2002 - ASBMB
Secretory granules of neuroendocrine cells are inositol 1, 4, 5-trisphosphate (InsP 3)-
sensitive Ca 2+ stores in which the Ca 2+ storage protein, chromogranin A (CGA), couples
with InsP 3-gated Ca 2+ channels (InsP 3 R) located in the granule membrane. The
functional aspect of this coupling has been investigated via release studies and planar lipid
bilayer experiments in the presence and absence of CGA. CGA drastically increased the
release activity of the InsP 3 R by increasing the channel open probability by 9-fold and the …
sensitive Ca 2+ stores in which the Ca 2+ storage protein, chromogranin A (CGA), couples
with InsP 3-gated Ca 2+ channels (InsP 3 R) located in the granule membrane. The
functional aspect of this coupling has been investigated via release studies and planar lipid
bilayer experiments in the presence and absence of CGA. CGA drastically increased the
release activity of the InsP 3 R by increasing the channel open probability by 9-fold and the …
