In situ hybridization of rnRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia
SX Zhang, JP Zhang, DL Fletcher, RT Zoeller… - Molecular brain …, 1995 - Elsevier
Loss of intracellular calcium homeostasis has been regarded an important factor underlying
neuron cell death after cerebral ischemic insult. In the brain, a major mechanism for
regulation of intracellular calcium is through the signal transduction pathway involving
hydrolysis of poly-phosphoinositides and release of the second messenger, inositol 1, 4, 5-
trisphosphate (IP3). IP3 mobilizes calcium by interacting with an intracellular receptor. Upon
its release after agonist stimulation, this second messenger is catabolized by a 3-kinase and …
neuron cell death after cerebral ischemic insult. In the brain, a major mechanism for
regulation of intracellular calcium is through the signal transduction pathway involving
hydrolysis of poly-phosphoinositides and release of the second messenger, inositol 1, 4, 5-
trisphosphate (IP3). IP3 mobilizes calcium by interacting with an intracellular receptor. Upon
its release after agonist stimulation, this second messenger is catabolized by a 3-kinase and …
