[HTML][HTML] Foxl1 controls the Wnt/β-catenin pathway by modulating the expression of proteoglycans in the gut
N Perreault, JP Katz, SD Sackett… - Journal of Biological …, 2001 - ASBMB
Foxl1 is a winged helix transcription factor expressed in the mesenchyme of the
gastrointestinal tract. Foxl1 null mice display severe structural defects in the epithelia of the
stomach, duodenum, and jejunum. Here we addressed the molecular mechanisms by which
Foxl1 controls gastrointestinal differentiation. First we showed that the abnormalities found in
the epithelia of the null mice are the result of an increase in the number of proliferating cells
and not a change in the rate of cell migration. Next we investigated the regulatory circuits …
gastrointestinal tract. Foxl1 null mice display severe structural defects in the epithelia of the
stomach, duodenum, and jejunum. Here we addressed the molecular mechanisms by which
Foxl1 controls gastrointestinal differentiation. First we showed that the abnormalities found in
the epithelia of the null mice are the result of an increase in the number of proliferating cells
and not a change in the rate of cell migration. Next we investigated the regulatory circuits …
