Background: Airway goblet cell hypersecretion may contribute to the pathophysiology of
asthma. However, it is unknown whether histamine affects goblet cell secretion and, if so,
which subtype of histamine receptor is involved and whether endogenous histamine-
degrading enzymes modulate these actions. Methods: We morphometrically assessed
goblet cell secretion in the guinea pig trachea stained with alcian blue and periodic acid
Schiff stains by measuring the mucus score, which was inversely related to the degree of …