[HTML][HTML] The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts: loss of …
JA Trejo, AJ Connolly, SR Coughlin - Journal of Biological Chemistry, 1996 - ASBMB
The mitogenic activity of thrombin on fibroblasts and smooth muscle cells may contribute to
embryonic development and normal wound healing, and it may also play a role in
pathological responses to vascular injury. To examine the importance of thrombin signaling
in vivo and to define the cloned thrombin receptor's role, we disrupted the thrombin receptor
gene (tr) in mice. Platelets from tr−/− mice responded normally to thrombin, but tr−/−
fibroblasts showed no thrombin-induced calcium mobilization or phosphoinositide …
embryonic development and normal wound healing, and it may also play a role in
pathological responses to vascular injury. To examine the importance of thrombin signaling
in vivo and to define the cloned thrombin receptor's role, we disrupted the thrombin receptor
gene (tr) in mice. Platelets from tr−/− mice responded normally to thrombin, but tr−/−
fibroblasts showed no thrombin-induced calcium mobilization or phosphoinositide …
