The gastrointestinal tract is critical to the pathogenesis of acute HIV-1 infection
S Mehandru, K Tenner-Racz, P Racz… - Journal of allergy and …, 2005 - Elsevier
It has become evident that the gastrointestinal tract is preferentially and profoundly depleted
of CD4+ T cells during acute HIV-1 infection. The enhanced susceptibility of gastrointestinal
lymphoid tissue to HIV-1 is in part due to the large complement of CCR5+ memory CD4+ T
cells resident at this site. Here we summarize the recent findings demonstrating that the
gastrointestinal tract plays a critical role in the pathogenesis of acute HIV-1 and simian
immunodeficiency virus infections. Ongoing work in this field is likely to have a significant …
of CD4+ T cells during acute HIV-1 infection. The enhanced susceptibility of gastrointestinal
lymphoid tissue to HIV-1 is in part due to the large complement of CCR5+ memory CD4+ T
cells resident at this site. Here we summarize the recent findings demonstrating that the
gastrointestinal tract plays a critical role in the pathogenesis of acute HIV-1 and simian
immunodeficiency virus infections. Ongoing work in this field is likely to have a significant …
