Characterization of [11C] tetrabenazine as an in vivo radioligand for the vesicular monoamine transporter
JN Dasilva, JE Carey, PS Sherman, TJ Pisani… - Nuclear medicine and …, 1994 - Elsevier
Abstract [11 C] Tetrabenazine ([11 C] TBZ) is a new in vivo radioligand for positron emission
tomographic (PET) imaging of vesicular monoamine transporters. The in vivo distribution,
metabolism and pharmacological specificity of [11 C] TBZ has been determined in rodents.
Regional mouse brain retention of [11 C] TBZ is highest in brain regions with greatest
monoaminergic innervation (striatum, hypothalamus) and can be reduced with ligands for
the monoamine vesicular transporter (TBZ, ketanserin) but not haloperidol, a dopamine D 2 …
tomographic (PET) imaging of vesicular monoamine transporters. The in vivo distribution,
metabolism and pharmacological specificity of [11 C] TBZ has been determined in rodents.
Regional mouse brain retention of [11 C] TBZ is highest in brain regions with greatest
monoaminergic innervation (striatum, hypothalamus) and can be reduced with ligands for
the monoamine vesicular transporter (TBZ, ketanserin) but not haloperidol, a dopamine D 2 …
