Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling …
SRJ Hoare, SK Sullivan, J Fan, K Khongsaly… - Peptides, 2005 - Elsevier
The CRF2 receptor is involved in stress responses, cardiovascular function and gastric
motility. Endogenous agonists (urocortin (UCN) 2, UCN 3) and synthetic antagonists
(astressin2-B, antisauvagine-30) are selective for CRF2 over the CRF1 receptor. Peptide
ligand binding properties of the CRF2 receptor require further investigation, including ligand
affinity for endogenously expressed receptors, the effect of receptor–G-protein coupling on
ligand affinity, and the molecular basis of ligand selectivity. Ligand affinity for rat CRF2 (a) in …
motility. Endogenous agonists (urocortin (UCN) 2, UCN 3) and synthetic antagonists
(astressin2-B, antisauvagine-30) are selective for CRF2 over the CRF1 receptor. Peptide
ligand binding properties of the CRF2 receptor require further investigation, including ligand
affinity for endogenously expressed receptors, the effect of receptor–G-protein coupling on
ligand affinity, and the molecular basis of ligand selectivity. Ligand affinity for rat CRF2 (a) in …
