Developmental biology of the placenta and the origins of placental insufficiency
V Chaddha, S Viero, B Huppertz, J Kingdom - Seminars in Fetal and …, 2004 - Elsevier
Defects in all the trophoblast-differentiating pathways—endovascular, interstitial and
chorionic villous—play a role in the pathogenesis of early-onset intra-uterine growth
restriction (IUGR). There are two types of extravillous trophoblast: endovascular trophoblast,
that forms the definitive placenta by occlusion of the spiral arteriole at the implantation site,
and interstitial extravillous trophoblast, responsible for the anatomical erosion of the distal
spiral arteriole and the secretion of angiogenic and vasodilator signals to improve uterine …
chorionic villous—play a role in the pathogenesis of early-onset intra-uterine growth
restriction (IUGR). There are two types of extravillous trophoblast: endovascular trophoblast,
that forms the definitive placenta by occlusion of the spiral arteriole at the implantation site,
and interstitial extravillous trophoblast, responsible for the anatomical erosion of the distal
spiral arteriole and the secretion of angiogenic and vasodilator signals to improve uterine …
