CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
JW Oh, CM Seroogy, EH Meyer, O Akbari… - Journal of allergy and …, 2002 - Elsevier
Background: TH2 cells play a critical role in the pathogenesis of asthma, but the precise
immunologic mechanisms that inhibit TH2 cell function in vivo are not well understood.
Objective: The purpose of our studies was to determine whether T cells producing IL-10
regulate the development of asthma. Methods: We used gene therapy to generate
ovalbumin-specific CD4 T-helper cells to express IL-10, and we examined their capacity to
regulate allergen-induced airway hyperreactivity. Results: We demonstrated that the CD4 T …
immunologic mechanisms that inhibit TH2 cell function in vivo are not well understood.
Objective: The purpose of our studies was to determine whether T cells producing IL-10
regulate the development of asthma. Methods: We used gene therapy to generate
ovalbumin-specific CD4 T-helper cells to express IL-10, and we examined their capacity to
regulate allergen-induced airway hyperreactivity. Results: We demonstrated that the CD4 T …
