The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics
CA Bursill, KM Channon… - Current opinion in …, 2004 - journals.lww.com
CA Bursill, KM Channon, DR Greaves
Current opinion in lipidology, 2004•journals.lww.comRecent transgenic and gene knockout studies in murine models of atherosclerosis have
highlighted the importance of chemokines and their receptors in atherosclerosis. Genetic
evidence for a role of chemokines and their receptors in human population studies remains
under investigation. Identifying chemokine polymorphisms could help to determine
pathways that are important in atherosclerosis disease pathology and that may suggest
novel therapeutic targets.
highlighted the importance of chemokines and their receptors in atherosclerosis. Genetic
evidence for a role of chemokines and their receptors in human population studies remains
under investigation. Identifying chemokine polymorphisms could help to determine
pathways that are important in atherosclerosis disease pathology and that may suggest
novel therapeutic targets.
Summary
Recent transgenic and gene knockout studies in murine models of atherosclerosis have highlighted the importance of chemokines and their receptors in atherosclerosis. Genetic evidence for a role of chemokines and their receptors in human population studies remains under investigation. Identifying chemokine polymorphisms could help to determine pathways that are important in atherosclerosis disease pathology and that may suggest novel therapeutic targets.
Lippincott Williams & Wilkins