[HTML][HTML] Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases
A Morén, T Imamura, K Miyazono, CH Heldin… - Journal of Biological …, 2005 - ASBMB
Smad4 mediates signaling by the transforming growth factor-β (TGF-β) superfamily of
cytokines. Smad signaling is negatively regulated by inhibitory (I) Smads and ubiquitin-
mediated processes. Known mechanisms of proteasomal degradation of Smads depend on
the direct interaction of specific E3 ligases with Smads. Alternatively, I-Smads elicit
degradation of the TGF-β receptor by recruiting the WW and HECT domain E3 ligases,
Smurfs, WWP1, or NEDD4–2. We describe an equivalent mechanism of degradation of …
cytokines. Smad signaling is negatively regulated by inhibitory (I) Smads and ubiquitin-
mediated processes. Known mechanisms of proteasomal degradation of Smads depend on
the direct interaction of specific E3 ligases with Smads. Alternatively, I-Smads elicit
degradation of the TGF-β receptor by recruiting the WW and HECT domain E3 ligases,
Smurfs, WWP1, or NEDD4–2. We describe an equivalent mechanism of degradation of …
