[HTML][HTML] Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells
L Zhang, X Pan, JWB Hershey - Journal of biological chemistry, 2007 - ASBMB
Transcriptional and post-transcriptional regulatory mechanisms are commonly accepted
paradigms of tumorigenesis. The view is emerging that deregulation of translation
contributes importantly to cancer development, a role not generally appreciated before.
Eukaryotic initiation factor eIF3 contains at least thirteen non-identical subunits, named from
eIF3a to eIF3m, and plays an essential role in the rate-limiting initiation phase of translation.
Increased mRNA and protein levels of the eIF3a,-3b,-3c,-3h, and-3i subunits have been …
paradigms of tumorigenesis. The view is emerging that deregulation of translation
contributes importantly to cancer development, a role not generally appreciated before.
Eukaryotic initiation factor eIF3 contains at least thirteen non-identical subunits, named from
eIF3a to eIF3m, and plays an essential role in the rate-limiting initiation phase of translation.
Increased mRNA and protein levels of the eIF3a,-3b,-3c,-3h, and-3i subunits have been …
