Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell …
R Bernabeu, T Yang, Y Xie, B Mehta, SY Ma… - Molecular and Cellular …, 2006 - Elsevier
Growth factors stimulating neurogenesis act through protein tyrosine kinases which are
counterbalanced by protein tyrosine phosphatases (PTPs); thus, downregulation of
progenitor PTP function might provide a novel strategy for promoting neurogenesis. We
tested the hypotheses that the leukocyte common antigen-related (LAR) PTP is present in
adult dentate gyrus progenitors, and that its downregulation would promote neurogenesis. In
adult mice, LAR immunostaining was present in Ki-67-and PCNA-positive subgranular zone …
counterbalanced by protein tyrosine phosphatases (PTPs); thus, downregulation of
progenitor PTP function might provide a novel strategy for promoting neurogenesis. We
tested the hypotheses that the leukocyte common antigen-related (LAR) PTP is present in
adult dentate gyrus progenitors, and that its downregulation would promote neurogenesis. In
adult mice, LAR immunostaining was present in Ki-67-and PCNA-positive subgranular zone …
