[HTML][HTML] Branched-chain amino acid metabolism: implications for establishing safe intakes
SM Hutson, AJ Sweatt, KF LaNoue - The Journal of nutrition, 2005 - Elsevier
There are several features of the metabolism of the indispensable BCAAs that set them apart
from other indispensable amino acids. BCAA catabolism involves 2 initial enzymatic steps
that are common to all 3 BCAAs; therefore, the dietary intake of an individual BCAA impacts
on the catabolism of all 3. The first step is reversible transamination followed by irreversible
oxidative decarboxylation of the branched-chain α-keto acid transamination products, the
branched chain α-keto acids (BCKAs). The BCAA catabolic enzymes are distributed widely …
from other indispensable amino acids. BCAA catabolism involves 2 initial enzymatic steps
that are common to all 3 BCAAs; therefore, the dietary intake of an individual BCAA impacts
on the catabolism of all 3. The first step is reversible transamination followed by irreversible
oxidative decarboxylation of the branched-chain α-keto acid transamination products, the
branched chain α-keto acids (BCKAs). The BCAA catabolic enzymes are distributed widely …