A molecular model of human branched-chain amino acid metabolism
A Suryawan, JW Hawes, RA Harris… - The American journal of …, 1998 - Elsevier
To establish an accurate molecular model of human branched-chain amino acid (BCAA)
metabolism, the distribution, activity, and expression of the first 2 enzymes in the catabolic
pathway—branched-chain-amino-acid aminotransferase (BCAT) and branched-chain α-keto
acid dehydrogenase (BCKD) complex—were determined in human tissues. The same
enzyme activities were measured in rat and African green monkey tissues. Overall, the
activities of BCAT and BCKD were higher in rat than in human and monkey tissues; …
metabolism, the distribution, activity, and expression of the first 2 enzymes in the catabolic
pathway—branched-chain-amino-acid aminotransferase (BCAT) and branched-chain α-keto
acid dehydrogenase (BCKD) complex—were determined in human tissues. The same
enzyme activities were measured in rat and African green monkey tissues. Overall, the
activities of BCAT and BCKD were higher in rat than in human and monkey tissues; …