Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles
AG Barschak, C Marchesan, A Sitta, M Deon… - Clinical …, 2008 - Elsevier
AG Barschak, C Marchesan, A Sitta, M Deon, R Giugliani, M Wajner, CR Vargas
Clinical biochemistry, 2008•ElsevierOBJECTIVE:: The objective of this study was to evaluate and correlate the biochemical and
oxidative stress profiles in MSUD patients during the dietary treatment. DESIGN AND
METHODS:: Plasma samples from treated MSUD patients were used to evaluate the
biochemical profile and oxidative stress parameters. RESULTS:: It was observed that
glucose, total cholesterol, albumin and creatinine are reduced and that aspartate
aminotransferase and lactate dehydrogenase activities are increased in plasma from MSUD …
oxidative stress profiles in MSUD patients during the dietary treatment. DESIGN AND
METHODS:: Plasma samples from treated MSUD patients were used to evaluate the
biochemical profile and oxidative stress parameters. RESULTS:: It was observed that
glucose, total cholesterol, albumin and creatinine are reduced and that aspartate
aminotransferase and lactate dehydrogenase activities are increased in plasma from MSUD …
OBJECTIVE
The objective of this study was to evaluate and correlate the biochemical and oxidative stress profiles in MSUD patients during the dietary treatment.
DESIGN AND METHODS
Plasma samples from treated MSUD patients were used to evaluate the biochemical profile and oxidative stress parameters.
RESULTS
It was observed that glucose, total cholesterol, albumin and creatinine are reduced and that aspartate aminotransferase and lactate dehydrogenase activities are increased in plasma from MSUD patients under treatment. Besides, it was verified an increase of thiobarbituric acid-reactive species (TBARS) and a decrease of total antioxidant reactivity (TAR).
CONCLUSIONS
Our results suggest that oxidative stress occurs in treated MSUD patients and that dietary treatment and clinical conditions associated to the disease can lead to biochemical alterations in these patients.
Elsevier