Positional mapping for amplified DNA sequences on 1q21–q22 in hepatocellular carcinoma indicates candidate genes over-expression
Background/Aims: Comparative genomic hybridization analysis on hepatocellular
carcinoma (HCC) indicated frequent gains of 1q and an amplicon at 1q21–q22. Current
cytogenetic evidences confer much importance on 1q21–q22, where a role in drug
resistance, tumor metastasis and shorter patient survival had been implicated. Methods:
Using positional mapping by interphase cytogenetics, we investigated the amplicon 1q21–
q22 in five HCC cases. Three amplification maxima represented by yeast artificial …
carcinoma (HCC) indicated frequent gains of 1q and an amplicon at 1q21–q22. Current
cytogenetic evidences confer much importance on 1q21–q22, where a role in drug
resistance, tumor metastasis and shorter patient survival had been implicated. Methods:
Using positional mapping by interphase cytogenetics, we investigated the amplicon 1q21–
q22 in five HCC cases. Three amplification maxima represented by yeast artificial …
