Pathways for bradykinin formation and inflammatory disease
AP Kaplan, K Joseph, M Silverberg - Journal of allergy and clinical …, 2002 - Elsevier
Bradykinin is formed by the interaction of factor XII, prekallikrein, and high-molecular-weight
kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or
macromolecular organic surfaces (heparin, other mucopolysaccharides, and sulfatides) or
on assembly along the surface of cells. Catalysis along the cell surface requires zinc-
dependent binding of factor XII and high-molecular-weight kininogen to proteins, such as the
receptor for the globular heads of the C1q subcomponent of complement, cytokeratin 1, and …
kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or
macromolecular organic surfaces (heparin, other mucopolysaccharides, and sulfatides) or
on assembly along the surface of cells. Catalysis along the cell surface requires zinc-
dependent binding of factor XII and high-molecular-weight kininogen to proteins, such as the
receptor for the globular heads of the C1q subcomponent of complement, cytokeratin 1, and …
