The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells
I Nahor, S Abramovitch, K Engeland… - Growth hormone & IGF …, 2005 - Elsevier
The insulin-like growth factor-I receptor (IGF-IR) has a critical role in malignant
transformation. Consistent with its antiapoptotic role, the IGF-IR gene is overexpressed in
most types of cancer, including colorectal tumors. The recently identified p53 homologues,
p63 and p73, exhibit some of the biological properties of p53, including the ability to
transactivate p53-responsive genes and to induce apoptosis. In the present study, we
examined the hypothesis that p63/p73 proteins may contribute to colon cancer cell …
transformation. Consistent with its antiapoptotic role, the IGF-IR gene is overexpressed in
most types of cancer, including colorectal tumors. The recently identified p53 homologues,
p63 and p73, exhibit some of the biological properties of p53, including the ability to
transactivate p53-responsive genes and to induce apoptosis. In the present study, we
examined the hypothesis that p63/p73 proteins may contribute to colon cancer cell …
