Metabolic and genetic regulation of cardiac energy substrate preference
IF Kodde, J van der Stok, RT Smolenski… - … and Physiology Part A …, 2007 - Elsevier
Proper heart function relies on high efficiency of energy conversion. Mitochondrial oxygen-
dependent processes transfer most of the chemical energy from metabolic substrates into
ATP. Healthy myocardium uses mainly fatty acids as its major energy source, with little
contribution of glucose. However, lactate, ketone bodies, amino acids or even acetate can
be oxidized under certain circumstances. A complex interplay exists between various
substrates responding to energy needs and substrate availability. The relative substrate …
dependent processes transfer most of the chemical energy from metabolic substrates into
ATP. Healthy myocardium uses mainly fatty acids as its major energy source, with little
contribution of glucose. However, lactate, ketone bodies, amino acids or even acetate can
be oxidized under certain circumstances. A complex interplay exists between various
substrates responding to energy needs and substrate availability. The relative substrate …