The peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of
adipogenesis and recruits coactivator proteins in response to ligand. However, the role of
another class of nuclear cofactors, the nuclear receptor corepressors, in modulating PPARγ
transcriptional activity is less clear. Such corepressors include the nuclear receptor
corepressor (NCoR) and the silencing mediator of retinoid and thyroid hormone receptors
(SMRT). Our data suggest that PPARγ recruits SMRT and NCoR in the absence of ligand …