[HTML][HTML] The AF-1 and AF-2 domains of RARγ2 and RXRα cooperate for triggering the transactivation and the degradation of RARγ2/RXRα heterodimers
M Gianní, A Tarrade, EA Nigro, E Garattini… - Journal of Biological …, 2003 - ASBMB
In eukaryotic cells, liganded RARγ2/RXRα heterodimers activate the transcription of retinoic
acid (RA) target genes and then are degraded through the ubiquitin-proteasome pathway. In
this study, we dissected the role of the RARγ2 and RXRα partners as well as of their
respective AF-1 and AF-2 domains in the processes of transactivation and degradation.
RARγ2 is the" engine" initiating transcription and its own degradation subsequent to ligand
binding. Integrity of its AF-2 domain and phosphorylation of its AF-1 domain are required for …
acid (RA) target genes and then are degraded through the ubiquitin-proteasome pathway. In
this study, we dissected the role of the RARγ2 and RXRα partners as well as of their
respective AF-1 and AF-2 domains in the processes of transactivation and degradation.
RARγ2 is the" engine" initiating transcription and its own degradation subsequent to ligand
binding. Integrity of its AF-2 domain and phosphorylation of its AF-1 domain are required for …