[HTML][HTML] The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications
E Honrado, J Benítez, J Palacios - Modern Pathology, 2005 - Elsevier
Cancer arising in carriers of mutations in the BRCA1 and BRCA2 genes differs from
sporadic breast cancer of age-matched controls and from non-BRCA1/2 familial breast
carcinomas in its morphological, immunophenotypic and molecular characteristics. Most
BRCA1 carcinomas have the basal cell phenotype, a subtype of high-grade, highly
proliferating, estrogen receptor-and HER2-negative breast carcinomas, characterized by the
expression of basal or myoepithelial markers such as basal keratins, P-cadherin, epidermal …
sporadic breast cancer of age-matched controls and from non-BRCA1/2 familial breast
carcinomas in its morphological, immunophenotypic and molecular characteristics. Most
BRCA1 carcinomas have the basal cell phenotype, a subtype of high-grade, highly
proliferating, estrogen receptor-and HER2-negative breast carcinomas, characterized by the
expression of basal or myoepithelial markers such as basal keratins, P-cadherin, epidermal …