Anoikis mechanisms
SM Frisch, RA Screaton - Current opinion in cell biology, 2001 - Elsevier
SM Frisch, RA Screaton
Current opinion in cell biology, 2001•ElsevierAnoikis is defined as apoptosis that is induced by inadequate or inappropriate cell–matrix
interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and
oncogenic processes. The central problem of anoikis is to understand how integrin-
mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of
the caspase cascade in anoikis remains to be explained.
interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and
oncogenic processes. The central problem of anoikis is to understand how integrin-
mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of
the caspase cascade in anoikis remains to be explained.
Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell–matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
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