Activated protein C (aPC) is the key effector protease of the natural protein C anticoagulant
pathway and exerts anticoagulant, as well as anti-inflammatory activity. This dual mode of
action has been thought to underlie the therapeutic efficacy of recombinant aPC in the
treatment of patients suffering from severe forms of sepsis. The development and
characterization of recombinant variants of aPC with altered bioactivity profiles has
generated an opportunity to test this concept by dissecting the roles of aPC's anticoagulant …