The restriction point of the cell cycle
MV Blagosklonny, AB Pardee - Cell cycle, 2002 - Taylor & Francis
MV Blagosklonny, AB Pardee
Cell cycle, 2002•Taylor & FrancisAs formulated in 1974, the concept of the restriction point of the cell cycle was based on cell
biological experiments, yet allowing accurate molecular predictions and spurring a search
for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as
outlined here is more interesting and far more complex. We discuss the relationship
between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of
the restriction point in cancer leads to loss of checkpoint control and to insensitivity to …
biological experiments, yet allowing accurate molecular predictions and spurring a search
for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as
outlined here is more interesting and far more complex. We discuss the relationship
between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of
the restriction point in cancer leads to loss of checkpoint control and to insensitivity to …
As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell biological experiments, yet allowing accurate molecular predictions and spurring a search for the restriction factor. Although cyclin D meets the criteria of the R-factor, the picture as outlined here is more interesting and far more complex. We discuss the relationship between the restriction knot and DNA damage-checkpoints. Finally, we discuss how loss of the restriction point in cancer leads to loss of checkpoint control and to insensitivity to antimitogens including some mechanism-based anticancer therapeutics.
Key Words:
Cell cycle, Cyclins, Growth factors, Oncogenes
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