Notch signaling in leukemia
JC Aster, WS Pear, SC Blacklow - Annu. Rev. Pathol. Mech. Dis., 2008 - annualreviews.org
JC Aster, WS Pear, SC Blacklow
Annu. Rev. Pathol. Mech. Dis., 2008•annualreviews.orgRecent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very
common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses
what these mutations have taught us about normal and pathophysiologic Notch1 signaling,
and how these insights may lead to new targeted therapies for patients with this aggressive
form of cancer.
common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses
what these mutations have taught us about normal and pathophysiologic Notch1 signaling,
and how these insights may lead to new targeted therapies for patients with this aggressive
form of cancer.
Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this aggressive form of cancer.
Annual Reviews