Translocation between chromosomes 8q24 and 14q11 in T-cell acute lymphoblastic leukemia
T Inaba, S Murakami, N Oku, K Itoh, Y Ura… - Cancer genetics and …, 1990 - Elsevier
Cytogenetic study was performed on a patient with T-cell acute lymphoblastic leukemia (T-
ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and
14q11. 8q24 is known to encode the oncogene c-myc, while 14q11 encodes the genes for T-
cell receptor-α (TCR-α) and T-cell receptor-δ (TCR-δ). Therefore, this chromosomal
translocation t (8; 14)(q24; q11) seemed to be unique and specific to T-cell malignancy.
ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and
14q11. 8q24 is known to encode the oncogene c-myc, while 14q11 encodes the genes for T-
cell receptor-α (TCR-α) and T-cell receptor-δ (TCR-δ). Therefore, this chromosomal
translocation t (8; 14)(q24; q11) seemed to be unique and specific to T-cell malignancy.