We were impressed with the reports of the German investigators concerning this compound, derived from quinolin, particularly in regard to the intensity of anæsthesia. It is to be noted, however, that not all the reports showed uniformly successful results; also where failures were recorded, faulty technic was generally blamed as the cause of failure. Some have found that a 1-2ooo solution for infiltration purposes, despite statements to the contrary, does not equal the anæsthetic activity of o. 5 per cent. procaine. Suffice it to say, that, for infiltration purposes, in a limited series of cases, we have found 1 per cent. procaine more satisfactory and have given up the use of nupercaine by this route. Nupercaine has been used for spinal, caudal, paravertebral and infiltration anaesthesia, also for topical application to mucous membranes. We have been impressed with the statement that the substance, prepared by Karl Miescher, is five times more toxic than cocaine and having ten times the activity of the latter drug. However, subsequent work on animals, together with its clinical use, would indicate that the margin of safety in its use, as prescribed, is much greater than the figures given. With the maximum dose of cocaine fixed at 5o milligrams, the maximum dose for nupercaine would, therefore, be 1o milligrams. This latter dose is contained in 2 cubic centimetres of o, 5 per cent. solution (used by us in ampoule form for spinal anæsthesia). This dose would also be contained in