Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia
RB Ness, BM Sibai - American journal of obstetrics and gynecology, 2006 - Elsevier
Intrauterine growth restriction (IUGR) and preeclampsia differ in their association with
maternal disease but share a similar placental pathology. Moreover, mothers who have had
pregnancies complicated by preeclampsia or IUGR are at elevated later-life cardiovascular
risk. Why, then, do some women develop IUGR and others develop preeclampsia? In this
clinical opinion, based on a review of the literature, we hypothesize that both women
experiencing preeclampsia and IUGR enter pregnancy with some degree of endothelial …
maternal disease but share a similar placental pathology. Moreover, mothers who have had
pregnancies complicated by preeclampsia or IUGR are at elevated later-life cardiovascular
risk. Why, then, do some women develop IUGR and others develop preeclampsia? In this
clinical opinion, based on a review of the literature, we hypothesize that both women
experiencing preeclampsia and IUGR enter pregnancy with some degree of endothelial …