Human leukocyte antigens and drug hypersensitivity
WH Chung, SI Hung, YT Chen - Current opinion in allergy and …, 2007 - journals.lww.com
WH Chung, SI Hung, YT Chen
Current opinion in allergy and clinical immunology, 2007•journals.lww.comThe strong genetic association suggests a direct involvement of HLA in the pathogenesis of
drug hypersensitivity when the HLA molecule presents an antigenic drug for T cell activation.
The high sensitivity/specificity of some markers provides a plausible basis for developing
tests to identify individuals at risk for drug hypersensitivity. Application of HLA-B* 1502
genotyping as a screening tool before prescribing carbamazepine could be a valuable tool
in preventing carbamazepine-induced SJS/TEN in south-east Asian countries.
drug hypersensitivity when the HLA molecule presents an antigenic drug for T cell activation.
The high sensitivity/specificity of some markers provides a plausible basis for developing
tests to identify individuals at risk for drug hypersensitivity. Application of HLA-B* 1502
genotyping as a screening tool before prescribing carbamazepine could be a valuable tool
in preventing carbamazepine-induced SJS/TEN in south-east Asian countries.
Summary
The strong genetic association suggests a direct involvement of HLA in the pathogenesis of drug hypersensitivity when the HLA molecule presents an antigenic drug for T cell activation. The high sensitivity/specificity of some markers provides a plausible basis for developing tests to identify individuals at risk for drug hypersensitivity. Application of HLA-B* 1502 genotyping as a screening tool before prescribing carbamazepine could be a valuable tool in preventing carbamazepine-induced SJS/TEN in south-east Asian countries.
Lippincott Williams & Wilkins