Creation and maintenance of psoriatic plaques require a multicellular conspiracy by which
prepsoriatic skin becomes infiltrated by a variety of immunocytes triggering changes in the
behavior of epidermal keratinocytes and endothelial cells. These complex cellular events
require coordination in space and time to achieve the mature plaque. Key molecular
coordinators dictating behavior and movement of cells within plaques include cytokines as
well as chemokines. These mediators of inflammation play fundamentally important roles in …