[HTML][HTML] Rac1 function is required for Src-induced transformation: evidence of a role for Tiam1 and Vav2 in Rac activation by Src
The proto-oncogene c-Src has been implicated in the development and progression of a
number of human cancers including those of colon and breast. Accumulating evidence
indicates that activated alleles of Src may induce cell transformation through Ras-ERK-
dependent and-independent pathways. Here we show that Rac1 activity is strongly elevated
in Src-transformed cells and that this small G protein is a critical component of the pathway
connecting oncogenic Src with cell transformation. We further show that Vav2 and the …
number of human cancers including those of colon and breast. Accumulating evidence
indicates that activated alleles of Src may induce cell transformation through Ras-ERK-
dependent and-independent pathways. Here we show that Rac1 activity is strongly elevated
in Src-transformed cells and that this small G protein is a critical component of the pathway
connecting oncogenic Src with cell transformation. We further show that Vav2 and the …