Role of thymus-derived lymphocytes in the secondary humoral immune response in mice
MC Raff - Nature, 1970 - nature.com
Nature, 1970•nature.com
THERE is now good evidence that the theta (θ) isoantigen of mice1 is carried only by those
peripheral lymphocytes which are thymus-derived2–4, so that anti-θ antiserum should be
useful in elucidating the role of these cells in immunity. In experiments reported here, anti-θ
has been used in vitro in an adoptive transfer system5 to study the function of thymus-
derived lymphocytes in the secondary humoral immune response to hapten–protein
conjugates, particularly in terms of cellular cooperation and carrier effects.
peripheral lymphocytes which are thymus-derived2–4, so that anti-θ antiserum should be
useful in elucidating the role of these cells in immunity. In experiments reported here, anti-θ
has been used in vitro in an adoptive transfer system5 to study the function of thymus-
derived lymphocytes in the secondary humoral immune response to hapten–protein
conjugates, particularly in terms of cellular cooperation and carrier effects.
Abstract
THERE is now good evidence that the theta (θ) isoantigen of mice1 is carried only by those peripheral lymphocytes which are thymus-derived2–4, so that anti-θ antiserum should be useful in elucidating the role of these cells in immunity. In experiments reported here, anti-θ has been used in vitro in an adoptive transfer system5 to study the function of thymus-derived lymphocytes in the secondary humoral immune response to hapten–protein conjugates, particularly in terms of cellular cooperation and carrier effects.
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