In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects
N Lopez-Souza, S Favoreto, H Wong, T Ward… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Human rhinoviruses (HRVs) characteristically cause upper respiratory tract
infection, but they also infect the lower airways, causing acute bronchitis and exacerbating
asthma. OBJECTIVE: Our purpose was to study ex vivo the differences in the response to
HRV infection of nasal and bronchial epithelial cultures from the same healthy and asthmatic
individuals using conditions favoring development of fully differentiated, pseudostratified
mucociliary epithelium. METHODS: Cells from the inferior turbinates and bronchial tree of 5 …
infection, but they also infect the lower airways, causing acute bronchitis and exacerbating
asthma. OBJECTIVE: Our purpose was to study ex vivo the differences in the response to
HRV infection of nasal and bronchial epithelial cultures from the same healthy and asthmatic
individuals using conditions favoring development of fully differentiated, pseudostratified
mucociliary epithelium. METHODS: Cells from the inferior turbinates and bronchial tree of 5 …
