Transcriptional regulatory networks are the central regulatory mechanisms that control organ
identity, patterning, and differentiation. In the case of the thymus, several key transcription
factors have been identified that are critical for various aspects of thymus organogenesis
and thymic epithelial cell (TEC) differentiation. The thymus forms from the third pharyngeal
pouch endoderm during embryogenesis. Organ development progresses from initial thymus
cell fate specification, through multiple stages of TEC differentiation and cortical (cTEC) and …