[HTML][HTML] Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
JY Chan, M Kwong, R Lu, J Chang, B Wang… - The EMBO …, 1998 - embopress.org
JY Chan, M Kwong, R Lu, J Chang, B Wang, TSB Yen, YW Kan
The EMBO journal, 1998•embopress.orgThe CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified
from independent searches for factors that bind the AP-1-like cis-elements in the β-globin
locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in
mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1
and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1,
targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are …
from independent searches for factors that bind the AP-1-like cis-elements in the β-globin
locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in
mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1
and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1,
targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are …
The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the β-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide range of tissues. To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero.
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