Neutrophils secreting tumor necrosis factor alpha infiltrate the central nervous system of BALB/c mice with experimental autoimmune encephalomyelitis
JA Määttä, UR Sjöholm, PT Nygårdas, AA Salmi… - Journal of …, 1998 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) can be induced in resistant BALB/c
mice by ultrasound-formed adjuvant emulsion. In contrast to susceptible mouse strains large
numbers of neutrophils secreting TNF-α occupied the central nervous system (CNS) of
BALB/c mice with severe EAE, whereas only small numbers of macrophages and CD4+ T-
cells could be detected. CNS infiltration was preceded with activation of microglial cells.
Ultrasound formed adjuvant induced early IFN-γ expression in popliteal lymph nodes of …
mice by ultrasound-formed adjuvant emulsion. In contrast to susceptible mouse strains large
numbers of neutrophils secreting TNF-α occupied the central nervous system (CNS) of
BALB/c mice with severe EAE, whereas only small numbers of macrophages and CD4+ T-
cells could be detected. CNS infiltration was preceded with activation of microglial cells.
Ultrasound formed adjuvant induced early IFN-γ expression in popliteal lymph nodes of …