[HTML][HTML] Bone marrow aplasia induced by passenger leukocytes from heart allografts
S Ko, MH Dahlke, O Lauth, MD Jäger, A Deiwick… - Experimental …, 2001 - Elsevier
OBJECTIVE: Organ allografts contain passenger leukocytes that are transferred to the
recipient with the transplantation, but their functional relevance to the recipient's immune
system is still controversial. MATERIALS AND METHODS: To clarify the functional capacity
of passenger leukocytes, we attempted to enhance their effect in rat heart allograft recipients
by selective depletion of recipient leukocytes using a monoclonal antibody (mAb) against a
recipient-specific allotype of CD45 (RT7a). RESULTS: Although antibody treatment of the …
recipient with the transplantation, but their functional relevance to the recipient's immune
system is still controversial. MATERIALS AND METHODS: To clarify the functional capacity
of passenger leukocytes, we attempted to enhance their effect in rat heart allograft recipients
by selective depletion of recipient leukocytes using a monoclonal antibody (mAb) against a
recipient-specific allotype of CD45 (RT7a). RESULTS: Although antibody treatment of the …